Whole exome sequencing in childhood-onset lupus frequently detects single gene etiologies
Identifieur interne : 000275 ( Main/Exploration ); précédent : 000274; suivant : 000276Whole exome sequencing in childhood-onset lupus frequently detects single gene etiologies
Auteurs : Irit Tirosh [Israël] ; Shiri Spielman [Israël] ; Ortal Barel [Israël] ; Reut Ram [Israël] ; Tali Stauber [Israël] ; Gideon Paret [Israël] ; Marina Rubinsthein [Israël] ; Itai M. Pessach [Israël] ; Maya Gerstein [Israël] ; Yair Anikster [Israël] ; Rachel Shukrun [Israël] ; Adi Dagan [Israël] ; Katerina Adler [Israël] ; Ben Pode-Shakked [Israël] ; Alexander Volkov [Israël] ; Marina Perelman [Israël] ; Shoshana Greenberger [Israël] ; Raz Somech [Israël] ; Einat Lahav [Israël] ; Amar J. Majmundar [États-Unis] ; Shai Padeh [Israël] ; Friedhelm Hildebrandt [États-Unis] ; Asaf Vivante [Israël]Source :
- Pediatric Rheumatology Online Journal [ 1546-0096 ] ; 2019.
Abstract
Systemic lupus erythematosus (SLE) comprise a diverse range of clinical manifestations. To date, more than 30 single gene causes of lupus/lupus like syndromes in humans have been identified. In the clinical setting, identifying the underlying molecular diagnosis is challenging due to phenotypic and genetic heterogeneity.
We employed whole exome sequencing (WES) in patients presenting with childhood-onset lupus with severe and/or atypical presentations to identify cases that are explained by a single-gene (monogenic) cause.
From January 2015 to June 2018 15 new cases of childhood-onset SLE were diagnosed in Edmond and Lily Safra Children’s Hospital. By WES we identified causative mutations in four subjects in five different genes:
We identified a significant fraction of monogenic SLE etiologies using WES and confirm the genetic locus heterogeneity in childhood-onset lupus. These results highlight the importance of establishing a genetic diagnosis for children with severe or atypical lupus by providing accurate and early etiology-based diagnoses and improving subsequent clinical management.
Url:
DOI: 10.1186/s12969-019-0349-y
PubMed: 31362757
PubMed Central: 6668194
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000161
- to stream Pmc, to step Curation: 000161
- to stream Pmc, to step Checkpoint: 000240
- to stream Ncbi, to step Merge: 000859
- to stream Ncbi, to step Curation: 000859
- to stream Ncbi, to step Checkpoint: 000859
- to stream Main, to step Merge: 000275
- to stream Main, to step Curation: 000275
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Whole exome sequencing in childhood-onset lupus frequently detects single gene etiologies</title><author><name sortKey="Tirosh, Irit" sort="Tirosh, Irit" uniqKey="Tirosh I" first="Irit" last="Tirosh">Irit Tirosh</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Rheumatology Unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Spielman, Shiri" sort="Spielman, Shiri" uniqKey="Spielman S" first="Shiri" last="Spielman">Shiri Spielman</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Rheumatology Unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Barel, Ortal" sort="Barel, Ortal" uniqKey="Barel O" first="Ortal" last="Barel">Ortal Barel</name><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>The Genomic Unit, Sheba Cancer Research Center,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel Hashomer</wicri:regionArea></affiliation></author><author><name sortKey="Ram, Reut" sort="Ram, Reut" uniqKey="Ram R" first="Reut" last="Ram">Reut Ram</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation></author><author><name sortKey="Stauber, Tali" sort="Stauber, Tali" uniqKey="Stauber T" first="Tali" last="Stauber">Tali Stauber</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics A Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Paret, Gideon" sort="Paret, Gideon" uniqKey="Paret G" first="Gideon" last="Paret">Gideon Paret</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Intensive care unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Rubinsthein, Marina" sort="Rubinsthein, Marina" uniqKey="Rubinsthein M" first="Marina" last="Rubinsthein">Marina Rubinsthein</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Intensive care unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Pessach, Itai M" sort="Pessach, Itai M" uniqKey="Pessach I" first="Itai M." last="Pessach">Itai M. Pessach</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Intensive care unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Gerstein, Maya" sort="Gerstein, Maya" uniqKey="Gerstein M" first="Maya" last="Gerstein">Maya Gerstein</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Anikster, Yair" sort="Anikster, Yair" uniqKey="Anikster Y" first="Yair" last="Anikster">Yair Anikster</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Metabolic Disease Unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Shukrun, Rachel" sort="Shukrun, Rachel" uniqKey="Shukrun R" first="Rachel" last="Shukrun">Rachel Shukrun</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Dagan, Adi" sort="Dagan, Adi" uniqKey="Dagan A" first="Adi" last="Dagan">Adi Dagan</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Adler, Katerina" sort="Adler, Katerina" uniqKey="Adler K" first="Katerina" last="Adler">Katerina Adler</name><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>The Genomic Unit, Sheba Cancer Research Center,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel Hashomer</wicri:regionArea></affiliation></author><author><name sortKey="Pode Shakked, Ben" sort="Pode Shakked, Ben" uniqKey="Pode Shakked B" first="Ben" last="Pode-Shakked">Ben Pode-Shakked</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Metabolic Disease Unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Volkov, Alexander" sort="Volkov, Alexander" uniqKey="Volkov A" first="Alexander" last="Volkov">Alexander Volkov</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Pathology Department,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Perelman, Marina" sort="Perelman, Marina" uniqKey="Perelman M" first="Marina" last="Perelman">Marina Perelman</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Pathology Department,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Greenberger, Shoshana" sort="Greenberger, Shoshana" uniqKey="Greenberger S" first="Shoshana" last="Greenberger">Shoshana Greenberger</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Dermatology,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Somech, Raz" sort="Somech, Raz" uniqKey="Somech R" first="Raz" last="Somech">Raz Somech</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics A Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Lahav, Einat" sort="Lahav, Einat" uniqKey="Lahav E" first="Einat" last="Lahav">Einat Lahav</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics A Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Nephrology Unit, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine, Sheba Medical Center, Tel Hashomer,</institution></institution-wrap>5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>5265601 Ramat Gan</wicri:regionArea></affiliation></author><author><name sortKey="Majmundar, Amar J" sort="Majmundar, Amar J" uniqKey="Majmundar A" first="Amar J." last="Majmundar">Amar J. Majmundar</name><affiliation wicri:level="2"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id><institution-id institution-id-type="GRID">grid.38142.3c</institution-id><institution>Division of Nephrology, Department of Medicine, Boston Children’s Hospital,</institution><institution>Harvard Medical School,</institution></institution-wrap>Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation></author><author><name sortKey="Padeh, Shai" sort="Padeh, Shai" uniqKey="Padeh S" first="Shai" last="Padeh">Shai Padeh</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Hildebrandt, Friedhelm" sort="Hildebrandt, Friedhelm" uniqKey="Hildebrandt F" first="Friedhelm" last="Hildebrandt">Friedhelm Hildebrandt</name><affiliation wicri:level="2"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id><institution-id institution-id-type="GRID">grid.38142.3c</institution-id><institution>Division of Nephrology, Department of Medicine, Boston Children’s Hospital,</institution><institution>Harvard Medical School,</institution></institution-wrap>Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation></author><author><name sortKey="Vivante, Asaf" sort="Vivante, Asaf" uniqKey="Vivante A" first="Asaf" last="Vivante">Asaf Vivante</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Nephrology Unit, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine, Sheba Medical Center, Tel Hashomer,</institution></institution-wrap>5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>5265601 Ramat Gan</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31362757</idno><idno type="pmc">6668194</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668194</idno><idno type="RBID">PMC:6668194</idno><idno type="doi">10.1186/s12969-019-0349-y</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000161</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000161</idno><idno type="wicri:Area/Pmc/Curation">000161</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000161</idno><idno type="wicri:Area/Pmc/Checkpoint">000240</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000240</idno><idno type="wicri:Area/Ncbi/Merge">000859</idno><idno type="wicri:Area/Ncbi/Curation">000859</idno><idno type="wicri:Area/Ncbi/Checkpoint">000859</idno><idno type="wicri:Area/Main/Merge">000275</idno><idno type="wicri:Area/Main/Curation">000275</idno><idno type="wicri:Area/Main/Exploration">000275</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Whole exome sequencing in childhood-onset lupus frequently detects single gene etiologies</title><author><name sortKey="Tirosh, Irit" sort="Tirosh, Irit" uniqKey="Tirosh I" first="Irit" last="Tirosh">Irit Tirosh</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Rheumatology Unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Spielman, Shiri" sort="Spielman, Shiri" uniqKey="Spielman S" first="Shiri" last="Spielman">Shiri Spielman</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Rheumatology Unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Barel, Ortal" sort="Barel, Ortal" uniqKey="Barel O" first="Ortal" last="Barel">Ortal Barel</name><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>The Genomic Unit, Sheba Cancer Research Center,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel Hashomer</wicri:regionArea></affiliation></author><author><name sortKey="Ram, Reut" sort="Ram, Reut" uniqKey="Ram R" first="Reut" last="Ram">Reut Ram</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation></author><author><name sortKey="Stauber, Tali" sort="Stauber, Tali" uniqKey="Stauber T" first="Tali" last="Stauber">Tali Stauber</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics A Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Paret, Gideon" sort="Paret, Gideon" uniqKey="Paret G" first="Gideon" last="Paret">Gideon Paret</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Intensive care unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Rubinsthein, Marina" sort="Rubinsthein, Marina" uniqKey="Rubinsthein M" first="Marina" last="Rubinsthein">Marina Rubinsthein</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Intensive care unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Pessach, Itai M" sort="Pessach, Itai M" uniqKey="Pessach I" first="Itai M." last="Pessach">Itai M. Pessach</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Intensive care unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Gerstein, Maya" sort="Gerstein, Maya" uniqKey="Gerstein M" first="Maya" last="Gerstein">Maya Gerstein</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Anikster, Yair" sort="Anikster, Yair" uniqKey="Anikster Y" first="Yair" last="Anikster">Yair Anikster</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Metabolic Disease Unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Shukrun, Rachel" sort="Shukrun, Rachel" uniqKey="Shukrun R" first="Rachel" last="Shukrun">Rachel Shukrun</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Dagan, Adi" sort="Dagan, Adi" uniqKey="Dagan A" first="Adi" last="Dagan">Adi Dagan</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Adler, Katerina" sort="Adler, Katerina" uniqKey="Adler K" first="Katerina" last="Adler">Katerina Adler</name><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>The Genomic Unit, Sheba Cancer Research Center,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel Hashomer</wicri:regionArea></affiliation></author><author><name sortKey="Pode Shakked, Ben" sort="Pode Shakked, Ben" uniqKey="Pode Shakked B" first="Ben" last="Pode-Shakked">Ben Pode-Shakked</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Metabolic Disease Unit, Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Volkov, Alexander" sort="Volkov, Alexander" uniqKey="Volkov A" first="Alexander" last="Volkov">Alexander Volkov</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Pathology Department,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Perelman, Marina" sort="Perelman, Marina" uniqKey="Perelman M" first="Marina" last="Perelman">Marina Perelman</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Pathology Department,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Greenberger, Shoshana" sort="Greenberger, Shoshana" uniqKey="Greenberger S" first="Shoshana" last="Greenberger">Shoshana Greenberger</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Dermatology,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Somech, Raz" sort="Somech, Raz" uniqKey="Somech R" first="Raz" last="Somech">Raz Somech</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics A Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Lahav, Einat" sort="Lahav, Einat" uniqKey="Lahav E" first="Einat" last="Lahav">Einat Lahav</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics A Edmond and Lily Safra Children’s Hospital,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Nephrology Unit, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine, Sheba Medical Center, Tel Hashomer,</institution></institution-wrap>5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>5265601 Ramat Gan</wicri:regionArea></affiliation></author><author><name sortKey="Majmundar, Amar J" sort="Majmundar, Amar J" uniqKey="Majmundar A" first="Amar J." last="Majmundar">Amar J. Majmundar</name><affiliation wicri:level="2"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id><institution-id institution-id-type="GRID">grid.38142.3c</institution-id><institution>Division of Nephrology, Department of Medicine, Boston Children’s Hospital,</institution><institution>Harvard Medical School,</institution></institution-wrap>Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation></author><author><name sortKey="Padeh, Shai" sort="Padeh, Shai" uniqKey="Padeh S" first="Shai" last="Padeh">Shai Padeh</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation></author><author><name sortKey="Hildebrandt, Friedhelm" sort="Hildebrandt, Friedhelm" uniqKey="Hildebrandt F" first="Friedhelm" last="Hildebrandt">Friedhelm Hildebrandt</name><affiliation wicri:level="2"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id><institution-id institution-id-type="GRID">grid.38142.3c</institution-id><institution>Division of Nephrology, Department of Medicine, Boston Children’s Hospital,</institution><institution>Harvard Medical School,</institution></institution-wrap>Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation></author><author><name sortKey="Vivante, Asaf" sort="Vivante, Asaf" uniqKey="Vivante A" first="Asaf" last="Vivante">Asaf Vivante</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Department of Pediatrics B, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine,</institution><institution>Sheba Medical Center,</institution></institution-wrap>Tel-Hashomer, 5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Hashomer, 5265601 Ramat Gan</wicri:regionArea><wicri:noRegion>5265601 Ramat Gan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id><institution-id institution-id-type="GRID">grid.12136.37</institution-id><institution>Sackler Faculty of Medicine,</institution><institution>Tel-Aviv University,</institution></institution-wrap>Tel-Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel-Aviv</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 2845</institution-id><institution-id institution-id-type="GRID">grid.413795.d</institution-id><institution>Nephrology Unit, Edmond and Lily Safra Children’s Hospital, Sackler Faculty of Medicine, Sheba Medical Center, Tel Hashomer,</institution></institution-wrap>5265601 Ramat Gan, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>5265601 Ramat Gan</wicri:regionArea></affiliation></author></analytic><series><title level="j">Pediatric Rheumatology Online Journal</title><idno type="eISSN">1546-0096</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Systemic lupus erythematosus (SLE) comprise a diverse range of clinical manifestations. To date, more than 30 single gene causes of lupus/lupus like syndromes in humans have been identified. In the clinical setting, identifying the underlying molecular diagnosis is challenging due to phenotypic and genetic heterogeneity.</p></sec><sec><title>Methods</title><p id="Par2">We employed whole exome sequencing (WES) in patients presenting with childhood-onset lupus with severe and/or atypical presentations to identify cases that are explained by a single-gene (monogenic) cause.</p></sec><sec><title>Results</title><p id="Par3">From January 2015 to June 2018 15 new cases of childhood-onset SLE were diagnosed in Edmond and Lily Safra Children’s Hospital. By WES we identified causative mutations in four subjects in five different genes: <italic>C1QC</italic>, <italic>SLC7A7</italic>, <italic>MAN2B1</italic>, <italic>PTEN</italic> and <italic>STAT1</italic>. No molecular diagnoses were established on clinical grounds prior to genetic testing.</p></sec><sec><title>Conclusions</title><p id="Par4">We identified a significant fraction of monogenic SLE etiologies using WES and confirm the genetic locus heterogeneity in childhood-onset lupus. These results highlight the importance of establishing a genetic diagnosis for children with severe or atypical lupus by providing accurate and early etiology-based diagnoses and improving subsequent clinical management.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tsokos, Gc" uniqKey="Tsokos G">GC Tsokos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bundhun, Pk" uniqKey="Bundhun P">PK Bundhun</name></author><author><name sortKey="Kumari, A" uniqKey="Kumari A">A Kumari</name></author><author><name sortKey="Huang, F" uniqKey="Huang F">F Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perry, D" uniqKey="Perry D">D Perry</name></author><author><name sortKey="Sang, A" uniqKey="Sang A">A Sang</name></author><author><name sortKey="Yin, Y" uniqKey="Yin Y">Y Yin</name></author><author><name sortKey="Zheng, Yy" uniqKey="Zheng Y">YY Zheng</name></author><author><name sortKey="Morel, L" uniqKey="Morel L">L Morel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santiago Raber, Ml" uniqKey="Santiago Raber M">ML Santiago-Raber</name></author><author><name sortKey="Laporte, C" uniqKey="Laporte C">C Laporte</name></author><author><name sortKey="Reininger, L" uniqKey="Reininger L">L Reininger</name></author><author><name sortKey="Izui, S" uniqKey="Izui S">S Izui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costa Reis, P" uniqKey="Costa Reis P">P Costa-Reis</name></author><author><name sortKey="Sullivan, Ke" uniqKey="Sullivan K">KE Sullivan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lo, Ms" uniqKey="Lo M">MS Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vivante, A" uniqKey="Vivante A">A Vivante</name></author><author><name sortKey="Hwang, Dy" uniqKey="Hwang D">DY Hwang</name></author><author><name sortKey="Kohl, S" uniqKey="Kohl S">S Kohl</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Shril, S" uniqKey="Shril S">S Shril</name></author><author><name sortKey="Schulz, J" uniqKey="Schulz J">J Schulz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author><author><name sortKey="Wilson, J" uniqKey="Wilson J">J Wilson</name></author><author><name sortKey="He, J" uniqKey="He J">J He</name></author><author><name sortKey="Xiang, L" uniqKey="Xiang L">L Xiang</name></author><author><name sortKey="Schur, Ph" uniqKey="Schur P">PH Schur</name></author><author><name sortKey="Mountz, Jd" uniqKey="Mountz J">JD Mountz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liaw, D" uniqKey="Liaw D">D Liaw</name></author><author><name sortKey="Marsh, Dj" uniqKey="Marsh D">DJ Marsh</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Dahia, Pl" uniqKey="Dahia P">PL Dahia</name></author><author><name sortKey="Wang, Si" uniqKey="Wang S">SI Wang</name></author><author><name sortKey="Zheng, Z" uniqKey="Zheng Z">Z Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author><author><name sortKey="Okada, S" uniqKey="Okada S">S Okada</name></author><author><name sortKey="Kong, Xf" uniqKey="Kong X">XF Kong</name></author><author><name sortKey="Kreins, Ay" uniqKey="Kreins A">AY Kreins</name></author><author><name sortKey="Cypowyj, S" uniqKey="Cypowyj S">S Cypowyj</name></author><author><name sortKey="Abhyankar, A" uniqKey="Abhyankar A">A Abhyankar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bowness, P" uniqKey="Bowness P">P Bowness</name></author><author><name sortKey="Davies, Ka" uniqKey="Davies K">KA Davies</name></author><author><name sortKey="Norsworthy, Pj" uniqKey="Norsworthy P">PJ Norsworthy</name></author><author><name sortKey="Athanassiou, P" uniqKey="Athanassiou P">P Athanassiou</name></author><author><name sortKey="Taylor Wiedeman, J" uniqKey="Taylor Wiedeman J">J Taylor-Wiedeman</name></author><author><name sortKey="Borysiewicz, Lk" uniqKey="Borysiewicz L">LK Borysiewicz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Batu, Ed" uniqKey="Batu E">ED Batu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Truedsson, L" uniqKey="Truedsson L">L Truedsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lukkarinen, M" uniqKey="Lukkarinen M">M Lukkarinen</name></author><author><name sortKey="Parto, K" uniqKey="Parto K">K Parto</name></author><author><name sortKey="Ruuskanen, O" uniqKey="Ruuskanen O">O Ruuskanen</name></author><author><name sortKey="Vainio, O" uniqKey="Vainio O">O Vainio</name></author><author><name sortKey="Kayhty, H" uniqKey="Kayhty H">H Kayhty</name></author><author><name sortKey="Olander, Rm" uniqKey="Olander R">RM Olander</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Urushihara, M" uniqKey="Urushihara M">M Urushihara</name></author><author><name sortKey="Kagami, S" uniqKey="Kagami S">S Kagami</name></author><author><name sortKey="Yasutomo, K" uniqKey="Yasutomo K">K Yasutomo</name></author><author><name sortKey="Ito, M" uniqKey="Ito M">M Ito</name></author><author><name sortKey="Kondo, S" uniqKey="Kondo S">S Kondo</name></author><author><name sortKey="Kitamura, A" uniqKey="Kitamura A">A Kitamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Posey, Je" uniqKey="Posey J">JE Posey</name></author><author><name sortKey="Harel, T" uniqKey="Harel T">T Harel</name></author><author><name sortKey="Liu, P" uniqKey="Liu P">P Liu</name></author><author><name sortKey="Rosenfeld, Ja" uniqKey="Rosenfeld J">JA Rosenfeld</name></author><author><name sortKey="James, Ra" uniqKey="James R">RA James</name></author><author><name sortKey="Coban Akdemir, Zh" uniqKey="Coban Akdemir Z">ZH Coban Akdemir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ceccarini, Maria" uniqKey="Ceccarini M">Maria Ceccarini</name></author><author><name sortKey="Codini, Michela" uniqKey="Codini M">Michela Codini</name></author><author><name sortKey="Conte, Carmela" uniqKey="Conte C">Carmela Conte</name></author><author><name sortKey="Patria, Federica" uniqKey="Patria F">Federica Patria</name></author><author><name sortKey="Cataldi, Samuela" uniqKey="Cataldi S">Samuela Cataldi</name></author><author><name sortKey="Bertelli, Matteo" uniqKey="Bertelli M">Matteo Bertelli</name></author><author><name sortKey="Albi, Elisabetta" uniqKey="Albi E">Elisabetta Albi</name></author><author><name sortKey="Beccari, Tommaso" uniqKey="Beccari T">Tommaso Beccari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eissing, M" uniqKey="Eissing M">M Eissing</name></author><author><name sortKey="Ripken, L" uniqKey="Ripken L">L Ripken</name></author><author><name sortKey="Schreibelt, G" uniqKey="Schreibelt G">G Schreibelt</name></author><author><name sortKey="Westdorp, H" uniqKey="Westdorp H">H Westdorp</name></author><author><name sortKey="Ligtenberg, M" uniqKey="Ligtenberg M">M Ligtenberg</name></author><author><name sortKey="Netea Maier, R" uniqKey="Netea Maier R">R Netea-Maier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Xn" uniqKey="Wu X">XN Wu</name></author><author><name sortKey="Ye, Yx" uniqKey="Ye Y">YX Ye</name></author><author><name sortKey="Niu, Jw" uniqKey="Niu J">JW Niu</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="You, X" uniqKey="You X">X You</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Veerdonk, Fl" uniqKey="Van De Veerdonk F">FL van de Veerdonk</name></author><author><name sortKey="Plantinga, Ts" uniqKey="Plantinga T">TS Plantinga</name></author><author><name sortKey="Hoischen, A" uniqKey="Hoischen A">A Hoischen</name></author><author><name sortKey="Smeekens, Sp" uniqKey="Smeekens S">SP Smeekens</name></author><author><name sortKey="Joosten, La" uniqKey="Joosten L">LA Joosten</name></author><author><name sortKey="Gilissen, C" uniqKey="Gilissen C">C Gilissen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Toubiana, J" uniqKey="Toubiana J">J Toubiana</name></author><author><name sortKey="Okada, S" uniqKey="Okada S">S Okada</name></author><author><name sortKey="Hiller, J" uniqKey="Hiller J">J Hiller</name></author><author><name sortKey="Oleastro, M" uniqKey="Oleastro M">M Oleastro</name></author><author><name sortKey="Lagos Gomez, M" uniqKey="Lagos Gomez M">M Lagos Gomez</name></author><author><name sortKey="Aldave Becerra, Jc" uniqKey="Aldave Becerra J">JC Aldave Becerra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanimura, M" uniqKey="Tanimura M">M Tanimura</name></author><author><name sortKey="Dohi, K" uniqKey="Dohi K">K Dohi</name></author><author><name sortKey="Hirayama, M" uniqKey="Hirayama M">M Hirayama</name></author><author><name sortKey="Sato, Y" uniqKey="Sato Y">Y Sato</name></author><author><name sortKey="Sugiura, E" uniqKey="Sugiura E">E Sugiura</name></author><author><name sortKey="Nakajima, H" uniqKey="Nakajima H">H Nakajima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smyth, Ae" uniqKey="Smyth A">AE Smyth</name></author><author><name sortKey="Kaleviste, E" uniqKey="Kaleviste E">E Kaleviste</name></author><author><name sortKey="Snow, A" uniqKey="Snow A">A Snow</name></author><author><name sortKey="Kisand, K" uniqKey="Kisand K">K Kisand</name></author><author><name sortKey="Mcmahon, Cj" uniqKey="Mcmahon C">CJ McMahon</name></author><author><name sortKey="Cant, Aj" uniqKey="Cant A">AJ Cant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forbes, Lr" uniqKey="Forbes L">LR Forbes</name></author><author><name sortKey="Vogel, Tp" uniqKey="Vogel T">TP Vogel</name></author><author><name sortKey="Cooper, Ma" uniqKey="Cooper M">MA Cooper</name></author><author><name sortKey="Castro Wagner, J" uniqKey="Castro Wagner J">J Castro-Wagner</name></author><author><name sortKey="Schussler, E" uniqKey="Schussler E">E Schussler</name></author><author><name sortKey="Weinacht, Kg" uniqKey="Weinacht K">KG Weinacht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zoghi, S" uniqKey="Zoghi S">S Zoghi</name></author><author><name sortKey="Ziaee, V" uniqKey="Ziaee V">V Ziaee</name></author><author><name sortKey="Hirschmugl, T" uniqKey="Hirschmugl T">T Hirschmugl</name></author><author><name sortKey="Jimenez Heredia, R" uniqKey="Jimenez Heredia R">R Jimenez-Heredia</name></author><author><name sortKey="Krolo, A" uniqKey="Krolo A">A Krolo</name></author><author><name sortKey="Boztug, K" uniqKey="Boztug K">K Boztug</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Schaarenburg, Ra" uniqKey="Van Schaarenburg R">RA van Schaarenburg</name></author><author><name sortKey="Daha, Na" uniqKey="Daha N">NA Daha</name></author><author><name sortKey="Schonkeren, Jj" uniqKey="Schonkeren J">JJ Schonkeren</name></author><author><name sortKey="Nivine Levarht, Ew" uniqKey="Nivine Levarht E">EW Nivine Levarht</name></author><author><name sortKey="Van Gijlswijk Janssen, Dj" uniqKey="Van Gijlswijk Janssen D">DJ van Gijlswijk-Janssen</name></author><author><name sortKey="Kurreeman, Fa" uniqKey="Kurreeman F">FA Kurreeman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Schaarenburg, Ra" uniqKey="Van Schaarenburg R">RA van Schaarenburg</name></author><author><name sortKey="Magro Checa, C" uniqKey="Magro Checa C">C Magro-Checa</name></author><author><name sortKey="Bakker, Ja" uniqKey="Bakker J">JA Bakker</name></author><author><name sortKey="Teng, Yk" uniqKey="Teng Y">YK Teng</name></author><author><name sortKey="Bajema, Im" uniqKey="Bajema I">IM Bajema</name></author><author><name sortKey="Huizinga, Tw" uniqKey="Huizinga T">TW Huizinga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Yl" uniqKey="Wu Y">YL Wu</name></author><author><name sortKey="Brookshire, Bp" uniqKey="Brookshire B">BP Brookshire</name></author><author><name sortKey="Verani, Rr" uniqKey="Verani R">RR Verani</name></author><author><name sortKey="Arnett, Fc" uniqKey="Arnett F">FC Arnett</name></author><author><name sortKey="Yu, Cy" uniqKey="Yu C">CY Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amano, Mt" uniqKey="Amano M">MT Amano</name></author><author><name sortKey="Ferriani, Vp" uniqKey="Ferriani V">VP Ferriani</name></author><author><name sortKey="Florido, Mp" uniqKey="Florido M">MP Florido</name></author><author><name sortKey="Reis, Es" uniqKey="Reis E">ES Reis</name></author><author><name sortKey="Delcolli, Mi" uniqKey="Delcolli M">MI Delcolli</name></author><author><name sortKey="Azzolini, Ae" uniqKey="Azzolini A">AE Azzolini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Afzali, P" uniqKey="Afzali P">P Afzali</name></author><author><name sortKey="Isaeian, A" uniqKey="Isaeian A">A Isaeian</name></author><author><name sortKey="Sadeghi, P" uniqKey="Sadeghi P">P Sadeghi</name></author><author><name sortKey="Moazzami, B" uniqKey="Moazzami B">B Moazzami</name></author><author><name sortKey="Parvaneh, N" uniqKey="Parvaneh N">N Parvaneh</name></author><author><name sortKey="Robatjazi, M" uniqKey="Robatjazi M">M Robatjazi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsukamoto, H" uniqKey="Tsukamoto H">H Tsukamoto</name></author><author><name sortKey="Horiuchi, T" uniqKey="Horiuchi T">T Horiuchi</name></author><author><name sortKey="Kokuba, H" uniqKey="Kokuba H">H Kokuba</name></author><author><name sortKey="Nagae, S" uniqKey="Nagae S">S Nagae</name></author><author><name sortKey="Nishizaka, H" uniqKey="Nishizaka H">H Nishizaka</name></author><author><name sortKey="Sawabe, T" uniqKey="Sawabe T">T Sawabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Lhotta, K" uniqKey="Lhotta K">K Lhotta</name></author><author><name sortKey="Chung, Ek" uniqKey="Chung E">EK Chung</name></author><author><name sortKey="Eder, P" uniqKey="Eder P">P Eder</name></author><author><name sortKey="Neumair, F" uniqKey="Neumair F">F Neumair</name></author><author><name sortKey="Yu, Cy" uniqKey="Yu C">CY Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeremiah, N" uniqKey="Jeremiah N">N Jeremiah</name></author><author><name sortKey="Neven, B" uniqKey="Neven B">B Neven</name></author><author><name sortKey="Gentili, M" uniqKey="Gentili M">M Gentili</name></author><author><name sortKey="Callebaut, I" uniqKey="Callebaut I">I Callebaut</name></author><author><name sortKey="Maschalidi, S" uniqKey="Maschalidi S">S Maschalidi</name></author><author><name sortKey="Stolzenberg, Mc" uniqKey="Stolzenberg M">MC Stolzenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramantani, G" uniqKey="Ramantani G">G Ramantani</name></author><author><name sortKey="Hausler, M" uniqKey="Hausler M">M Hausler</name></author><author><name sortKey="Niggemann, P" uniqKey="Niggemann P">P Niggemann</name></author><author><name sortKey="Wessling, B" uniqKey="Wessling B">B Wessling</name></author><author><name sortKey="Guttmann, H" uniqKey="Guttmann H">H Guttmann</name></author><author><name sortKey="Mull, M" uniqKey="Mull M">M Mull</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crow, Yj" uniqKey="Crow Y">YJ Crow</name></author><author><name sortKey="Chase, Ds" uniqKey="Chase D">DS Chase</name></author><author><name sortKey="Lowenstein Schmidt, J" uniqKey="Lowenstein Schmidt J">J Lowenstein Schmidt</name></author><author><name sortKey="Szynkiewicz, M" uniqKey="Szynkiewicz M">M Szynkiewicz</name></author><author><name sortKey="Forte, Gm" uniqKey="Forte G">GM Forte</name></author><author><name sortKey="Gornall, Hl" uniqKey="Gornall H">HL Gornall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Briggs, Ta" uniqKey="Briggs T">TA Briggs</name></author><author><name sortKey="Rice, Gi" uniqKey="Rice G">GI Rice</name></author><author><name sortKey="Daly, S" uniqKey="Daly S">S Daly</name></author><author><name sortKey="Urquhart, J" uniqKey="Urquhart J">J Urquhart</name></author><author><name sortKey="Gornall, H" uniqKey="Gornall H">H Gornall</name></author><author><name sortKey="Bader Meunier, B" uniqKey="Bader Meunier B">B Bader-Meunier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crow, Yj" uniqKey="Crow Y">YJ Crow</name></author><author><name sortKey="Livingston, Jh" uniqKey="Livingston J">JH Livingston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bodano, A" uniqKey="Bodano A">A Bodano</name></author><author><name sortKey="Amarelo, J" uniqKey="Amarelo J">J Amarelo</name></author><author><name sortKey="Gonzalez, A" uniqKey="Gonzalez A">A Gonzalez</name></author><author><name sortKey="Gomez Reino, Jj" uniqKey="Gomez Reino J">JJ Gomez-Reino</name></author><author><name sortKey="Conde, C" uniqKey="Conde C">C Conde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee Kirsch, Ma" uniqKey="Lee Kirsch M">MA Lee-Kirsch</name></author><author><name sortKey="Gong, M" uniqKey="Gong M">M Gong</name></author><author><name sortKey="Chowdhury, D" uniqKey="Chowdhury D">D Chowdhury</name></author><author><name sortKey="Senenko, L" uniqKey="Senenko L">L Senenko</name></author><author><name sortKey="Engel, K" uniqKey="Engel K">K Engel</name></author><author><name sortKey="Lee, Ya" uniqKey="Lee Y">YA Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gunther, C" uniqKey="Gunther C">C Gunther</name></author><author><name sortKey="Kind, B" uniqKey="Kind B">B Kind</name></author><author><name sortKey="Reijns, Ma" uniqKey="Reijns M">MA Reijns</name></author><author><name sortKey="Berndt, N" uniqKey="Berndt N">N Berndt</name></author><author><name sortKey="Martinez Bueno, M" uniqKey="Martinez Bueno M">M Martinez-Bueno</name></author><author><name sortKey="Wolf, C" uniqKey="Wolf C">C Wolf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bader Meunier, B" uniqKey="Bader Meunier B">B Bader-Meunier</name></author><author><name sortKey="Cave, H" uniqKey="Cave H">H Cave</name></author><author><name sortKey="Jeremiah, N" uniqKey="Jeremiah N">N Jeremiah</name></author><author><name sortKey="Magerus, A" uniqKey="Magerus A">A Magerus</name></author><author><name sortKey="Lanzarotti, N" uniqKey="Lanzarotti N">N Lanzarotti</name></author><author><name sortKey="Rieux Laucat, F" uniqKey="Rieux Laucat F">F Rieux-Laucat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brehm, A" uniqKey="Brehm A">A Brehm</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Sheikh, A" uniqKey="Sheikh A">A Sheikh</name></author><author><name sortKey="Marrero, B" uniqKey="Marrero B">B Marrero</name></author><author><name sortKey="Omoyinmi, E" uniqKey="Omoyinmi E">E Omoyinmi</name></author><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Mayouf, Sm" uniqKey="Al Mayouf S">SM Al-Mayouf</name></author><author><name sortKey="Alsaleem, A" uniqKey="Alsaleem A">A AlSaleem</name></author><author><name sortKey="Almutairi, N" uniqKey="Almutairi N">N AlMutairi</name></author><author><name sortKey="Alsonbul, A" uniqKey="Alsonbul A">A AlSonbul</name></author><author><name sortKey="Alzaid, T" uniqKey="Alzaid T">T Alzaid</name></author><author><name sortKey="Alazami, Am" uniqKey="Alazami A">AM Alazami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaishnaw, Ak" uniqKey="Vaishnaw A">AK Vaishnaw</name></author><author><name sortKey="Toubi, E" uniqKey="Toubi E">E Toubi</name></author><author><name sortKey="Ohsako, S" uniqKey="Ohsako S">S Ohsako</name></author><author><name sortKey="Drappa, J" uniqKey="Drappa J">J Drappa</name></author><author><name sortKey="Buys, S" uniqKey="Buys S">S Buys</name></author><author><name sortKey="Estrada, J" uniqKey="Estrada J">J Estrada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kiykim, A" uniqKey="Kiykim A">A Kiykim</name></author><author><name sortKey="Ogulur, I" uniqKey="Ogulur I">I Ogulur</name></author><author><name sortKey="Baris, S" uniqKey="Baris S">S Baris</name></author><author><name sortKey="Salzer, E" uniqKey="Salzer E">E Salzer</name></author><author><name sortKey="Karakoc Aydiner, E" uniqKey="Karakoc Aydiner E">E Karakoc-Aydiner</name></author><author><name sortKey="Ozen, Ao" uniqKey="Ozen A">AO Ozen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walter, Je" uniqKey="Walter J">JE Walter</name></author><author><name sortKey="Lo, Ms" uniqKey="Lo M">MS Lo</name></author><author><name sortKey="Kis Toth, K" uniqKey="Kis Toth K">K Kis-Toth</name></author><author><name sortKey="Tirosh, I" uniqKey="Tirosh I">I Tirosh</name></author><author><name sortKey="Frugoni, F" uniqKey="Frugoni F">F Frugoni</name></author><author><name sortKey="Lee, Yn" uniqKey="Lee Y">YN Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Ravin, Ss" uniqKey="De Ravin S">SS De Ravin</name></author><author><name sortKey="Naumann, N" uniqKey="Naumann N">N Naumann</name></author><author><name sortKey="Cowen, Ew" uniqKey="Cowen E">EW Cowen</name></author><author><name sortKey="Friend, J" uniqKey="Friend J">J Friend</name></author><author><name sortKey="Hilligoss, D" uniqKey="Hilligoss D">D Hilligoss</name></author><author><name sortKey="Marquesen, M" uniqKey="Marquesen M">M Marquesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Massaad, Mj" uniqKey="Massaad M">MJ Massaad</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Tsuchimoto, D" uniqKey="Tsuchimoto D">D Tsuchimoto</name></author><author><name sortKey="Chou, J" uniqKey="Chou J">J Chou</name></author><author><name sortKey="Jabara, H" uniqKey="Jabara H">H Jabara</name></author><author><name sortKey="Janssen, E" uniqKey="Janssen E">E Janssen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name></author><author><name sortKey="Gu, Z" uniqKey="Gu Z">Z Gu</name></author><author><name sortKey="Shen, B" uniqKey="Shen B">B Shen</name></author><author><name sortKey="Jiang, J" uniqKey="Jiang J">J Jiang</name></author><author><name sortKey="Meng, Y" uniqKey="Meng Y">Y Meng</name></author><author><name sortKey="Da, Z" uniqKey="Da Z">Z Da</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Di Rocco, M" uniqKey="Di Rocco M">M Di Rocco</name></author><author><name sortKey="Fantasia, Ar" uniqKey="Fantasia A">AR Fantasia</name></author><author><name sortKey="Taro, M" uniqKey="Taro M">M Taro</name></author><author><name sortKey="Loy, A" uniqKey="Loy A">A Loy</name></author><author><name sortKey="Forlino, A" uniqKey="Forlino A">A Forlino</name></author><author><name sortKey="Martini, A" uniqKey="Martini A">A Martini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aoki, M" uniqKey="Aoki M">M Aoki</name></author><author><name sortKey="Fukao, T" uniqKey="Fukao T">T Fukao</name></author><author><name sortKey="Fujita, Y" uniqKey="Fujita Y">Y Fujita</name></author><author><name sortKey="Watanabe, M" uniqKey="Watanabe M">M Watanabe</name></author><author><name sortKey="Teramoto, T" uniqKey="Teramoto T">T Teramoto</name></author><author><name sortKey="Kato, Y" uniqKey="Kato Y">Y Kato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Botto, M" uniqKey="Botto M">M Botto</name></author><author><name sortKey="Dell Agnola, C" uniqKey="Dell Agnola C">C Dell'Agnola</name></author><author><name sortKey="Bygrave, Ae" uniqKey="Bygrave A">AE Bygrave</name></author><author><name sortKey="Thompson, Em" uniqKey="Thompson E">EM Thompson</name></author><author><name sortKey="Cook, Ht" uniqKey="Cook H">HT Cook</name></author><author><name sortKey="Petry, F" uniqKey="Petry F">F Petry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name></author><author><name sortKey="Koralov, Sb" uniqKey="Koralov S">SB Koralov</name></author><author><name sortKey="Kelsoe, G" uniqKey="Kelsoe G">G Kelsoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higuchi, T" uniqKey="Higuchi T">T Higuchi</name></author><author><name sortKey="Aiba, Y" uniqKey="Aiba Y">Y Aiba</name></author><author><name sortKey="Nomura, T" uniqKey="Nomura T">T Nomura</name></author><author><name sortKey="Matsuda, J" uniqKey="Matsuda J">J Matsuda</name></author><author><name sortKey="Mochida, K" uniqKey="Mochida K">K Mochida</name></author><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salvador, Jm" uniqKey="Salvador J">JM Salvador</name></author><author><name sortKey="Hollander, Mc" uniqKey="Hollander M">MC Hollander</name></author><author><name sortKey="Nguyen, At" uniqKey="Nguyen A">AT Nguyen</name></author><author><name sortKey="Kopp, Jb" uniqKey="Kopp J">JB Kopp</name></author><author><name sortKey="Barisoni, L" uniqKey="Barisoni L">L Barisoni</name></author><author><name sortKey="Moore, Jk" uniqKey="Moore J">JK Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fanzo, Jc" uniqKey="Fanzo J">JC Fanzo</name></author><author><name sortKey="Yang, W" uniqKey="Yang W">W Yang</name></author><author><name sortKey="Jang, Sy" uniqKey="Jang S">SY Jang</name></author><author><name sortKey="Gupta, S" uniqKey="Gupta S">S Gupta</name></author><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name></author><author><name sortKey="Siddiq, A" uniqKey="Siddiq A">A Siddiq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Napirei, M" uniqKey="Napirei M">M Napirei</name></author><author><name sortKey="Karsunky, H" uniqKey="Karsunky H">H Karsunky</name></author><author><name sortKey="Zevnik, B" uniqKey="Zevnik B">B Zevnik</name></author><author><name sortKey="Stephan, H" uniqKey="Stephan H">H Stephan</name></author><author><name sortKey="Mannherz, Hg" uniqKey="Mannherz H">HG Mannherz</name></author><author><name sortKey="Moroy, T" uniqKey="Moroy T">T Moroy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forster, Nicole" uniqKey="Forster N">Nicole Forster</name></author><author><name sortKey="Gallinat, Sven" uniqKey="Gallinat S">Sven Gallinat</name></author><author><name sortKey="Jablonska, Jadwiga" uniqKey="Jablonska J">Jadwiga Jablonska</name></author><author><name sortKey="Weiss, Siegfried" uniqKey="Weiss S">Siegfried Weiss</name></author><author><name sortKey="Els Sser, Hans Peter" uniqKey="Els Sser H">Hans-Peter Elsässer</name></author><author><name sortKey="Lutz, Werner" uniqKey="Lutz W">Werner Lutz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sugino, Y" uniqKey="Sugino Y">Y Sugino</name></author><author><name sortKey="Nishikawa, N" uniqKey="Nishikawa N">N Nishikawa</name></author><author><name sortKey="Yoshimura, K" uniqKey="Yoshimura K">K Yoshimura</name></author><author><name sortKey="Kuno, S" uniqKey="Kuno S">S Kuno</name></author><author><name sortKey="Hayashi, Y" uniqKey="Hayashi Y">Y Hayashi</name></author><author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Funabiki, M" uniqKey="Funabiki M">M Funabiki</name></author><author><name sortKey="Kato, H" uniqKey="Kato H">H Kato</name></author><author><name sortKey="Miyachi, Y" uniqKey="Miyachi Y">Y Miyachi</name></author><author><name sortKey="Toki, H" uniqKey="Toki H">H Toki</name></author><author><name sortKey="Motegi, H" uniqKey="Motegi H">H Motegi</name></author><author><name sortKey="Inoue, M" uniqKey="Inoue M">M Inoue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, J" uniqKey="Sun J">J Sun</name></author><author><name sortKey="Matthias, G" uniqKey="Matthias G">G Matthias</name></author><author><name sortKey="Mihatsch, Mj" uniqKey="Mihatsch M">MJ Mihatsch</name></author><author><name sortKey="Georgopoulos, K" uniqKey="Georgopoulos K">K Georgopoulos</name></author><author><name sortKey="Matthias, P" uniqKey="Matthias P">P Matthias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sabrautzki, S" uniqKey="Sabrautzki S">S Sabrautzki</name></author><author><name sortKey="Janas, E" uniqKey="Janas E">E Janas</name></author><author><name sortKey="Lorenz Depiereux, B" uniqKey="Lorenz Depiereux B">B Lorenz-Depiereux</name></author><author><name sortKey="Calzada Wack, J" uniqKey="Calzada Wack J">J Calzada-Wack</name></author><author><name sortKey="Aguilar Pimentel, Ja" uniqKey="Aguilar Pimentel J">JA Aguilar-Pimentel</name></author><author><name sortKey="Rathkolb, B" uniqKey="Rathkolb B">B Rathkolb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pflegerl, P" uniqKey="Pflegerl P">P Pflegerl</name></author><author><name sortKey="Vesely, P" uniqKey="Vesely P">P Vesely</name></author><author><name sortKey="Hantusch, B" uniqKey="Hantusch B">B Hantusch</name></author><author><name sortKey="Schlederer, M" uniqKey="Schlederer M">M Schlederer</name></author><author><name sortKey="Zenz, R" uniqKey="Zenz R">R Zenz</name></author><author><name sortKey="Janig, E" uniqKey="Janig E">E Janig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, N" uniqKey="Singh N">N Singh</name></author><author><name sortKey="Johnstone, Db" uniqKey="Johnstone D">DB Johnstone</name></author><author><name sortKey="Martin, Ka" uniqKey="Martin K">KA Martin</name></author><author><name sortKey="Tempera, I" uniqKey="Tempera I">I Tempera</name></author><author><name sortKey="Kaplan, Mj" uniqKey="Kaplan M">MJ Kaplan</name></author><author><name sortKey="Denny, Mf" uniqKey="Denny M">MF Denny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charles, N" uniqKey="Charles N">N Charles</name></author><author><name sortKey="Hardwick, D" uniqKey="Hardwick D">D Hardwick</name></author><author><name sortKey="Daugas, E" uniqKey="Daugas E">E Daugas</name></author><author><name sortKey="Illei, Gg" uniqKey="Illei G">GG Illei</name></author><author><name sortKey="Rivera, J" uniqKey="Rivera J">J Rivera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chui, D" uniqKey="Chui D">D Chui</name></author><author><name sortKey="Sellakumar, G" uniqKey="Sellakumar G">G Sellakumar</name></author><author><name sortKey="Green, R" uniqKey="Green R">R Green</name></author><author><name sortKey="Sutton Smith, M" uniqKey="Sutton Smith M">M Sutton-Smith</name></author><author><name sortKey="Mcquistan, T" uniqKey="Mcquistan T">T McQuistan</name></author><author><name sortKey="Marek, K" uniqKey="Marek K">K Marek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Kovalev, Gi" uniqKey="Kovalev G">GI Kovalev</name></author><author><name sortKey="Chang, H" uniqKey="Chang H">H Chang</name></author><author><name sortKey="Kallin, E" uniqKey="Kallin E">E Kallin</name></author><author><name sortKey="Knudsen, G" uniqKey="Knudsen G">G Knudsen</name></author><author><name sortKey="Xia, L" uniqKey="Xia L">L Xia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author><author><name sortKey="Chikuma, S" uniqKey="Chikuma S">S Chikuma</name></author><author><name sortKey="Hori, S" uniqKey="Hori S">S Hori</name></author><author><name sortKey="Fagarasan, S" uniqKey="Fagarasan S">S Fagarasan</name></author><author><name sortKey="Honjo, T" uniqKey="Honjo T">T Honjo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Senejani, Ag" uniqKey="Senejani A">AG Senejani</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Kidane, D" uniqKey="Kidane D">D Kidane</name></author><author><name sortKey="Maher, Se" uniqKey="Maher S">SE Maher</name></author><author><name sortKey="Zeiss, Cj" uniqKey="Zeiss C">CJ Zeiss</name></author><author><name sortKey="Park, Hj" uniqKey="Park H">HJ Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roszer, T" uniqKey="Roszer T">T Roszer</name></author><author><name sortKey="Menendez Gutierrez, Mp" uniqKey="Menendez Gutierrez M">MP Menendez-Gutierrez</name></author><author><name sortKey="Lefterova, Mi" uniqKey="Lefterova M">MI Lefterova</name></author><author><name sortKey="Alameda, D" uniqKey="Alameda D">D Alameda</name></author><author><name sortKey="Nunez, V" uniqKey="Nunez V">V Nunez</name></author><author><name sortKey="Lazar, Ma" uniqKey="Lazar M">MA Lazar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Sj" uniqKey="Kim S">SJ Kim</name></author><author><name sortKey="Zou, Yr" uniqKey="Zou Y">YR Zou</name></author><author><name sortKey="Goldstein, J" uniqKey="Goldstein J">J Goldstein</name></author><author><name sortKey="Reizis, B" uniqKey="Reizis B">B Reizis</name></author><author><name sortKey="Diamond, B" uniqKey="Diamond B">B Diamond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zikherman, J" uniqKey="Zikherman J">J Zikherman</name></author><author><name sortKey="Hermiston, M" uniqKey="Hermiston M">M Hermiston</name></author><author><name sortKey="Steiner, D" uniqKey="Steiner D">D Steiner</name></author><author><name sortKey="Hasegawa, K" uniqKey="Hasegawa K">K Hasegawa</name></author><author><name sortKey="Chan, A" uniqKey="Chan A">A Chan</name></author><author><name sortKey="Weiss, A" uniqKey="Weiss A">A Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Layer, K" uniqKey="Layer K">K Layer</name></author><author><name sortKey="Lin, G" uniqKey="Lin G">G Lin</name></author><author><name sortKey="Nencioni, A" uniqKey="Nencioni A">A Nencioni</name></author><author><name sortKey="Hu, W" uniqKey="Hu W">W Hu</name></author><author><name sortKey="Schmucker, A" uniqKey="Schmucker A">A Schmucker</name></author><author><name sortKey="Antov, An" uniqKey="Antov A">AN Antov</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Vinuesa, Cg" uniqKey="Vinuesa C">CG Vinuesa</name></author><author><name sortKey="Cook, Mc" uniqKey="Cook M">MC Cook</name></author><author><name sortKey="Angelucci, C" uniqKey="Angelucci C">C Angelucci</name></author><author><name sortKey="Athanasopoulos, V" uniqKey="Athanasopoulos V">V Athanasopoulos</name></author><author><name sortKey="Rui, L" uniqKey="Rui L">L Rui</name></author><author><name sortKey="Hill, Km" uniqKey="Hill K">KM Hill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, X" uniqKey="Sun X">X Sun</name></author><author><name sortKey="Wiedeman, A" uniqKey="Wiedeman A">A Wiedeman</name></author><author><name sortKey="Agrawal, N" uniqKey="Agrawal N">N Agrawal</name></author><author><name sortKey="Teal, Th" uniqKey="Teal T">TH Teal</name></author><author><name sortKey="Tanaka, L" uniqKey="Tanaka L">L Tanaka</name></author><author><name sortKey="Hudkins, Kl" uniqKey="Hudkins K">KL Hudkins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seshasayee, D" uniqKey="Seshasayee D">D Seshasayee</name></author><author><name sortKey="Valdez, P" uniqKey="Valdez P">P Valdez</name></author><author><name sortKey="Yan, M" uniqKey="Yan M">M Yan</name></author><author><name sortKey="Dixit, Vm" uniqKey="Dixit V">VM Dixit</name></author><author><name sortKey="Tumas, D" uniqKey="Tumas D">D Tumas</name></author><author><name sortKey="Grewal, Is" uniqKey="Grewal I">IS Grewal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsushima, Y" uniqKey="Matsushima Y">Y Matsushima</name></author><author><name sortKey="Kikkawa, Y" uniqKey="Kikkawa Y">Y Kikkawa</name></author><author><name sortKey="Takada, T" uniqKey="Takada T">T Takada</name></author><author><name sortKey="Matsuoka, K" uniqKey="Matsuoka K">K Matsuoka</name></author><author><name sortKey="Seki, Y" uniqKey="Seki Y">Y Seki</name></author><author><name sortKey="Yoshida, H" uniqKey="Yoshida H">H Yoshida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xue, D" uniqKey="Xue D">D Xue</name></author><author><name sortKey="Shi, H" uniqKey="Shi H">H Shi</name></author><author><name sortKey="Smith, Jd" uniqKey="Smith J">JD Smith</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Noe, Da" uniqKey="Noe D">DA Noe</name></author><author><name sortKey="Cedervall, T" uniqKey="Cedervall T">T Cedervall</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Israël</li><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="Israël"><noRegion><name sortKey="Tirosh, Irit" sort="Tirosh, Irit" uniqKey="Tirosh I" first="Irit" last="Tirosh">Irit Tirosh</name></noRegion><name sortKey="Adler, Katerina" sort="Adler, Katerina" uniqKey="Adler K" first="Katerina" last="Adler">Katerina Adler</name><name sortKey="Anikster, Yair" sort="Anikster, Yair" uniqKey="Anikster Y" first="Yair" last="Anikster">Yair Anikster</name><name sortKey="Anikster, Yair" sort="Anikster, Yair" uniqKey="Anikster Y" first="Yair" last="Anikster">Yair Anikster</name><name sortKey="Barel, Ortal" sort="Barel, Ortal" uniqKey="Barel O" first="Ortal" last="Barel">Ortal Barel</name><name sortKey="Dagan, Adi" sort="Dagan, Adi" uniqKey="Dagan A" first="Adi" last="Dagan">Adi Dagan</name><name sortKey="Dagan, Adi" sort="Dagan, Adi" uniqKey="Dagan A" first="Adi" last="Dagan">Adi Dagan</name><name sortKey="Gerstein, Maya" sort="Gerstein, Maya" uniqKey="Gerstein M" first="Maya" last="Gerstein">Maya Gerstein</name><name sortKey="Gerstein, Maya" sort="Gerstein, Maya" uniqKey="Gerstein M" first="Maya" last="Gerstein">Maya Gerstein</name><name sortKey="Greenberger, Shoshana" sort="Greenberger, Shoshana" uniqKey="Greenberger S" first="Shoshana" last="Greenberger">Shoshana Greenberger</name><name sortKey="Greenberger, Shoshana" sort="Greenberger, Shoshana" uniqKey="Greenberger S" first="Shoshana" last="Greenberger">Shoshana Greenberger</name><name sortKey="Lahav, Einat" sort="Lahav, Einat" uniqKey="Lahav E" first="Einat" last="Lahav">Einat Lahav</name><name sortKey="Lahav, Einat" sort="Lahav, Einat" uniqKey="Lahav E" first="Einat" last="Lahav">Einat Lahav</name><name sortKey="Lahav, Einat" sort="Lahav, Einat" uniqKey="Lahav E" first="Einat" last="Lahav">Einat Lahav</name><name sortKey="Padeh, Shai" sort="Padeh, Shai" uniqKey="Padeh S" first="Shai" last="Padeh">Shai Padeh</name><name sortKey="Padeh, Shai" sort="Padeh, Shai" uniqKey="Padeh S" first="Shai" last="Padeh">Shai Padeh</name><name sortKey="Paret, Gideon" sort="Paret, Gideon" uniqKey="Paret G" first="Gideon" last="Paret">Gideon Paret</name><name sortKey="Paret, Gideon" sort="Paret, Gideon" uniqKey="Paret G" first="Gideon" last="Paret">Gideon Paret</name><name sortKey="Perelman, Marina" sort="Perelman, Marina" uniqKey="Perelman M" first="Marina" last="Perelman">Marina Perelman</name><name sortKey="Perelman, Marina" sort="Perelman, Marina" uniqKey="Perelman M" first="Marina" last="Perelman">Marina Perelman</name><name sortKey="Pessach, Itai M" sort="Pessach, Itai M" uniqKey="Pessach I" first="Itai M." last="Pessach">Itai M. Pessach</name><name sortKey="Pessach, Itai M" sort="Pessach, Itai M" uniqKey="Pessach I" first="Itai M." last="Pessach">Itai M. Pessach</name><name sortKey="Pode Shakked, Ben" sort="Pode Shakked, Ben" uniqKey="Pode Shakked B" first="Ben" last="Pode-Shakked">Ben Pode-Shakked</name><name sortKey="Pode Shakked, Ben" sort="Pode Shakked, Ben" uniqKey="Pode Shakked B" first="Ben" last="Pode-Shakked">Ben Pode-Shakked</name><name sortKey="Pode Shakked, Ben" sort="Pode Shakked, Ben" uniqKey="Pode Shakked B" first="Ben" last="Pode-Shakked">Ben Pode-Shakked</name><name sortKey="Ram, Reut" sort="Ram, Reut" uniqKey="Ram R" first="Reut" last="Ram">Reut Ram</name><name sortKey="Rubinsthein, Marina" sort="Rubinsthein, Marina" uniqKey="Rubinsthein M" first="Marina" last="Rubinsthein">Marina Rubinsthein</name><name sortKey="Rubinsthein, Marina" sort="Rubinsthein, Marina" uniqKey="Rubinsthein M" first="Marina" last="Rubinsthein">Marina Rubinsthein</name><name sortKey="Shukrun, Rachel" sort="Shukrun, Rachel" uniqKey="Shukrun R" first="Rachel" last="Shukrun">Rachel Shukrun</name><name sortKey="Shukrun, Rachel" sort="Shukrun, Rachel" uniqKey="Shukrun R" first="Rachel" last="Shukrun">Rachel Shukrun</name><name sortKey="Somech, Raz" sort="Somech, Raz" uniqKey="Somech R" first="Raz" last="Somech">Raz Somech</name><name sortKey="Somech, Raz" sort="Somech, Raz" uniqKey="Somech R" first="Raz" last="Somech">Raz Somech</name><name sortKey="Spielman, Shiri" sort="Spielman, Shiri" uniqKey="Spielman S" first="Shiri" last="Spielman">Shiri Spielman</name><name sortKey="Spielman, Shiri" sort="Spielman, Shiri" uniqKey="Spielman S" first="Shiri" last="Spielman">Shiri Spielman</name><name sortKey="Stauber, Tali" sort="Stauber, Tali" uniqKey="Stauber T" first="Tali" last="Stauber">Tali Stauber</name><name sortKey="Stauber, Tali" sort="Stauber, Tali" uniqKey="Stauber T" first="Tali" last="Stauber">Tali Stauber</name><name sortKey="Tirosh, Irit" sort="Tirosh, Irit" uniqKey="Tirosh I" first="Irit" last="Tirosh">Irit Tirosh</name><name sortKey="Tirosh, Irit" sort="Tirosh, Irit" uniqKey="Tirosh I" first="Irit" last="Tirosh">Irit Tirosh</name><name sortKey="Vivante, Asaf" sort="Vivante, Asaf" uniqKey="Vivante A" first="Asaf" last="Vivante">Asaf Vivante</name><name sortKey="Vivante, Asaf" sort="Vivante, Asaf" uniqKey="Vivante A" first="Asaf" last="Vivante">Asaf Vivante</name><name sortKey="Vivante, Asaf" sort="Vivante, Asaf" uniqKey="Vivante A" first="Asaf" last="Vivante">Asaf Vivante</name><name sortKey="Volkov, Alexander" sort="Volkov, Alexander" uniqKey="Volkov A" first="Alexander" last="Volkov">Alexander Volkov</name><name sortKey="Volkov, Alexander" sort="Volkov, Alexander" uniqKey="Volkov A" first="Alexander" last="Volkov">Alexander Volkov</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Majmundar, Amar J" sort="Majmundar, Amar J" uniqKey="Majmundar A" first="Amar J." last="Majmundar">Amar J. Majmundar</name></region><name sortKey="Hildebrandt, Friedhelm" sort="Hildebrandt, Friedhelm" uniqKey="Hildebrandt F" first="Friedhelm" last="Hildebrandt">Friedhelm Hildebrandt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000275 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000275 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6668194
|texte= Whole exome sequencing in childhood-onset lupus frequently detects single gene etiologies
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31362757" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |